2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110043
    (±)-Clopidogrel hydrochloride
    		Control
    (±)-Clopidogrel hydrochloride is an antithrombotic agent that is ADP-selective and orally available. (±)-Clopidogrel hydrochloride inhibits platelet aggregation by inhibiting the binding of ADP to its platelet receptors.
    (±)-Clopidogrel hydrochloride
  • HY-10064S1
    Ticagrelor-d4
    		Antagonist
    Ticagrelor-d4 (AZD6140-d4) is deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
    Ticagrelor-d<sub>4</sub>
  • HY-W419570
    (Rac)-BX 048
    		Antagonist
    (Rac)-BX 048 is a BX 048 racemate. BX 048 is a P2Y12 receptor antagonist. BX 048 inhibits ADP-induced platelet aggregation in human, dog and rat whole blood. BX 048 also inhibits Arachidonic acid (HY-109590) induced platelet aggregation (IC50 of 15 μM).
    (Rac)-BX 048
  • HY-148596
    UDP-GlcNAc
    		Agonist
    UDP-GlcNAc is an essential building block and precursor of bacterial peptidoglycan.
    UDP-GlcNAc
  • HY-137602
    P1,P2-Diuridine-5’-diphosphate
    		Activator
    P1,P2-Diuridine-5’-diphosphate (Up2U) is a symmetrical dinucleoside polyphosphate containing two pyrimidine base moieties. P1,P2-Diuridine-5’-diphosphate is also an activator of purinergic P2Y receptor.
    P1,P2-Diuridine-5’-diphosphate
  • HY-15284B
    Prasugrel (Maleic acid)
    		Inhibitor
    Prasugrel (PCR 4099) Maleic acid is a thienopyridine and proagent, inhibits platelet function. Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel (Maleic acid)
  • HY-19638AR
    Cangrelor tetrasodium (Standard)
    		Antagonist
    Cangrelor (tetrasodium) (Standard) is the analytical standard of Cangrelor (tetrasodium). This product is intended for research and analytical applications. Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist.
    Cangrelor tetrasodium (Standard)
  • HY-15283AS
    (±)-Clopidogrel-d7 sulfate
    (±)-Clopidogrel-d7 (sulfate) is the deuterium labeled (±)-Clopidogrel sulfate.
    (±)-Clopidogrel-d<sub>7</sub> sulfate
  • HY-137608
    Uridine 5'-O-thiodiphosphate
    		Agonist
    Uridine 5'-O-thiodiphosphate (UDP-β-S) is a stable analog of UDP. As a selective agonist of P2Y6 receptor, Uridine 5'-O-thiodiphosphate has higher metabolic stability and can be used in the study of cardiovascular diseases.
    Uridine 5'-O-thiodiphosphate
  • HY-137418
    2-MeS-ATP
    		Agonist
    2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.
    2-MeS-ATP
  • HY-W010832R
    Uridine-5'-diphosphate disodium salt (Standard)
    		Modulator
    Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
    Uridine-5'-diphosphate disodium salt (Standard)
  • HY-15284AR
    Prasugrel hydrochloride (Standard)
    		Inhibitor
    Prasugrel (hydrochloride) (Standard) is the analytical standard of Prasugrel (hydrochloride). This product is intended for research and analytical applications. Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and proagent, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel hydrochloride (Standard)
  • HY-116307
    2-Thio-UTP
    		Agonist
    2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .
    2-Thio-UTP
  • HY-131822
    5'-UMPS
    		Agonist
    5'-UMPS (Uridine-5'-O-monophosphorothioate) is a P2Y14 receptor agonist. 5'-UMPS can induce HeLa cell growth slightly.
    5'-UMPS
  • HY-111064
    BX 667
    		Antagonist
    BX 667 is an orally active reversible P2Y(12) receptor antagonist. BX 667 attenuates thrombosis.
    BX 667
  • HY-137626
    Sp-ATPαS
    		Antagonist
    Sp-ATPαS is a regulator of ATP-binding proteins. Sp-ATPαS is a competitive antagonist of the human P2Y1 receptor, which can inhibit the calcium signal induced by ADP. Sp-ATPαS is metabolically more stable than ATP. Sp-ATPαS can be used to study the binding patterns of metals and nucleotides in enzymatic reactions.
    Sp-ATPαS
  • HY-113723
    MRS2298
    		Antagonist
    MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca2+ rise in platelets with an IC50 of 810 nM.
    MRS2298
  • HY-154840A
    4-Thiouridine 5′-triphosphate tetrasodium
    		Agonist
    4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium (Compound 15) is a UTP analog and potent P2Y2 and P2Y4 agonist with EC50 values of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in cross-linking experiments and transcriptional complex labeling studies.
    4-Thiouridine 5′-triphosphate tetrasodium
  • HY-179053
    P2Y12/PDE5-IN-1
    		Inhibitor
    P2Y12/PDE5-IN-1 (Compound 10) is a dual-target inhibitor of P2Y12 (IC50 = 0.271 μg/mL) and PDE5 (IC50 = 0.154 μg/mL). P2Y12/PDE5-IN-1 can be used for research on anti-thrombosis and vasodilation.
    P2Y12/PDE5-IN-1
  • HY-137612
    Sp-UTP-α-S
    		Activator
    Sp-UTP-α-S is a P2Y2 and P2Y4 receptor activator. Sp-UTP-α-S can be used in cancer research.
    Sp-UTP-α-S
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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